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Séminaire Yi Wang

23 juin

Quantitative susceptibility mapping (QSM) : biometal imaging and its applications

Séminaire Yi Wang, Cornell University - Professeur invité à l’IMFT
(co-organisé IMFT unité INSERM TONIC)

Ce séminaire vise un public intéressé vers l’Imagerie par Résonance Magnétique de la Susceptibilité Magnétique.

Jeudi 29 Juin à 14 h 00

Salle de conférence du 1er étage, Pavillon Baudot, CHU Purpan

Summary : Quantitative susceptibility mapping (QSM) has enabled MRI of tissue magnetic susceptibility to advance from simple qualitative detection of hypointense blooming artifacts to precise quantitative measurement of spatial biodistributions. Tissue susceptibility contains rich functional and structural information pertinent to molecular electron cloud properties. The dominant tissue susceptibility sources are biometals, which are vital participants in cellular biochemistry and are involved in a variety of pathologic processes. QSM technology based on the Bayesian approach has been sufficiently developed and validated to warrant wide dissemination for clinical applications, particularly for imaging tissue biometals with high susceptibility values. QSM can be useful for diseases that involve neurodegeneration, inflammation, hemorrhage, abnormal oxygen consumption, substantial alterations in highly paramagnetic cellular iron, bone mineralization, or pathologic calcification ; and for all disorders in which MRI diagnosis or surveillance requires contrast agent injection. Clinicians should consider integrating QSM into their routine imaging practices by including gradient echo sequences in all relevant MRI protocols.